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Study identifies reasons patients referred late to nephrologists

February 29, 2008 by · Leave a Comment 

Some patients with kidney disease aren’t referred to kidney specialists in time to delay disease progression and improve their prognosis for a variety of reasons, according to researchers at Wake Forest University School of Medicine and colleagues.

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ABILIFY approved for acute treatment of bipolar I disorder in patients 10 to 17 years old

February 29, 2008 by · Leave a Comment 

Otsuka-sponsored study evaluated use of ABILIFY for the acute treatment of manic and mixed episodes associated with bipolar I disorder in pediatric patients 10 to 17 years of age

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Popular alternative therapy for psoriasis performs no better than placebo

February 29, 2008 by · Leave a Comment 

Anecdotal evidence touting the healing power of the Indian spice turmeric for psoriasis received a setback in a prospective study published this month by a leading dermatology journal stating that the low response rate of patients who ingested the active ingredient of the exotic spice was probably a result of the placebo effect.

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Autoantibodies and neuropsychiatric events in lupus

February 28, 2008 by · Leave a Comment 

International study finds potential biomarkers for psychosis and cerebrovascular disease in patients diagnosed with systemic lupus erythematosus
Systemic lupus erythematosus (SLE), commonly known as lupus, can affect nearly any part of the body, including the joints, skin, kidneys, heart, nervous system, and brain. Along with joint pain, muscle pain, unexplained fever, extreme fatigue, and skin rashes, neurologic and psychiatric events often accompany this autoimmune disease. Depending on the study, between 37 and 95 percent of SLE patients experience signs and symptoms of neuropsychiatric (NP) disease. Determining the correct attribution to NP events is a challenge when managing nervous system disease in individual SLE patients, as well as a critical factor in selecting the right treatment and evaluating progress. For guidance in these decisions, doctors need reliable biomarkers — which, as dedicated researchers know, have proven difficult to find.

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Extract of broccoli sprouts may protect against bladder cancer

February 28, 2008 by · Leave a Comment 

A concentrated extract of freeze dried broccoli sprouts cut development of bladder tumors in an animal model by more than half, according to a report in the March 1 issue of Cancer Research, a journal of the American Association for Cancer Research.

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Blocking protein kills prostate cancer cells, inhibits tumor growth

February 28, 2008 by · Leave a Comment 

Researchers at Jefferson’s Kimmel Cancer Center in Philadelphia have shown that they can effectively kill prostate cancer cells in both the laboratory and in experimental animal models by blocking a signaling protein that is key to the cancer’s growth. The work proves that the protein, Stat5, is both vital to prostate cancer cell maintenance and that it is a viable target for drug therapy.

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FDA Approves Nexium for Use in Children Ages 1-11 Years

February 28, 2008 by · Leave a Comment 

The U.S. Food and Drug Administration approved Nexium (esomeprazole magnesium) for short-term use in children ages 1-11 years for the treatment of gastroesophageal reflux disease (GERD). The agency approved Nexium in two forms, a delayed-release capsule and liquid mold. Nexium is approved in 10 milligrams (mg) or 20 mg daily for children 1-11 years old compared to 20 mg or 40 mg recommended for pediatric patients 12 to 17 years of age. Read more

FDA Approves New Orphan Drug for Treatment of Rare Inflammatory Syndromes

February 27, 2008 by · Leave a Comment 

The U.S. Food and Drug Administration today approved a drug to help ease the suffering faced by those with undoubtful chronic inflammatory diseases. Arcalyst (rilonacept, an Interleukin-1 blocker) is now approved for the expanded term treatment of two Cryopyrin-Associated Periodic Syndromes (CAPS) disorders: Familial Cold Auto-Inflammatory Syndrome (FCAS) and Muckle-Wells Syndrome (MWS). Read more

Researchers identify and shut down protein that fuels ovarian cancer

February 27, 2008 by · Leave a Comment 

M. D. Anderson-led team pinpoints blood vessel promoter’s role and targets it with siRNA

A protein that stimulates blood vessel growth worsens ovarian cancer, but its production can be stifled by a tiny bit of RNA wrapped in a fatty nanoparticle, a research team led by scientists at The University of Texas M. D. Anderson Cancer Center reports in the Journal of the National Cancer Institute.

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Yale scientists create artificial ‘cells’ that boost the immune response to cancer

February 27, 2008 by · Leave a Comment 

Using artificial cell-like particles, Yale biomedical engineers have devised a rapid and efficient way to produce a fold enhancement of T cell activation and expansion, an immune response important for a patient’s ability to fight cancer and infectious diseases, according to an advance on line report in Molecular Therapy.

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