Researchers report potential new treatment to stop Alzheimer’s disease

Last March, researchers at UCLA reported the development of a molecular compound called CLR01 that prevented toxic proteins associated with Parkinson’s disease from binding together and killing the brain’s neurons.

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Gene nearly triples risk of Alzheimer’s, global team including Mayo Clinic finds

 

A gene so powerful it nearly triples the risk of Alzheimer’s disease has been discovered by an international team including researchers from Mayo Clinic. It is the most potent genetic risk factor for Alzheimer’s identified in the past 20 years. The findings were reported Wednesday in the online edition of the New England Journal of Medicine.

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Looking for the anti-Alzheimer’s molecule — A new approach to treating a devastating disease

Alzheimer’s is a devastating disease for which no truly disease-modifying drugs are available. Our approach is completely novel. We explore how the human body attempts to protect itself from Alzheimer’s, and then we exploit this to develop an entirely new approach to therapeutics,” explained Dr. Weaver, a professor at Dalhousie University, clinical neurologist at Capital Health and IWK Health Centre, Canada Research Chair in Clinical Neuroscience, and the DMRF Irene MacDonald Sobey Chair in Curative Approaches to Alzheimer’s Disease. “We are extremely excited about the results presented in this paper and believe that this may represent a new approach to the treatment of AD.”

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Prospective Alzheimer’s drug builds new brain cell connections

 

Washington State University researchers have developed a new drug candidate that dramatically improves the cognitive function of rats with Alzheimer’s-like mental impairment.

Their compound, which is intended to repair brain damage that has already occurred, is a significant departure from current Alzheimer’s treatments, which either slow the process of cell death or inhibit cholinesterase, an enzyme believed to break down a key neurotransmitter involved in learning and memory development. Such drugs, says Joe Harding, a professor in WSU’s College of Veterinary Medicine, are not designed to restore lost brain function, which can be done by rebuilding connections between nerve cells.

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Investigational drugs chosen for major Alzheimer’s prevention trial

Leading scientists have selected the first drugs to be evaluated in a worldwide clinical study to determine whether they can prevent Alzheimer’s disease.

The pioneering trial, expected to start by early 2013, initially will test three promising drugs, each designed to target Alzheimer’s in different ways.

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Alzheimer’s disease in men linked to low levels of hormone, IGF-1

Low serum levels of insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3) are associated with Alzheimer’s Disease in men, but not women, according to a recent study accepted for publication in The Endocrine Society’s Journal of Clinical Endocrinology & Metabolism (JCEM).

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Why does Alzheimer’s disease affect twice as many women as men?

New Rochelle, NY, September 5, 2012?A group of experts has developed consensus recommendations for future research directions to determine why nearly two-thirds of Americans with Alzheimer’s disease (AD) are women. The recommendations are published in a Roundtable discussion in Journal of Women’s Health, a peer-reviewed publication from Mary Ann Liebert, Inc., publishers. The article is available free on the Journal of Women’s Health website at http://www.liebertpub.com/jwh.

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Blood test for Alzheimer’s gaining ground

The possibility of an inexpensive, convenient test for Alzheimer’s disease has been on the horizon for several years, but previous research leads have been hard to duplicate.

In a study to be published in the August 28 issue of the journal Neurology, scientists have taken a step toward developing a blood test for Alzheimer’s, finding a group of markers that hold up in statistical analyses in three independent groups of patients.

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Spice ingredient in curry emerges as promising basis for an Alzheimer’s disease medicine

The spice compound that gives curry dishes their yellow color and pungent flavor is emerging as a prime candidate for a less expensive treatment for Alzheimer’s disease (AD), according to an article in the current edition of Chemical & Engineering News. C&EN is the weekly newsmagazine of the American Chemical Society, the world’s largest scientific society.

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Small molecule may play big role in Alzheimer’s disease

 

Alzheimer’s disease is one of the most dreaded and debilitating illnesses one can develop. Currently, the disease afflicts 6.5 million Americans and the Alzheimer’s Association projects it to increase to between 11 and 16 million, or 1 in 85 people, by 2050.

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