New hope for taming triple-negative breast cancer

 

Disease-free survival is short-lived for women with triple-negative breast cancer ? a form of the disease that doesn’t respond to hormone drugs and becomes resistant to chemotherapy. Thankfully, a promising line of study in the School of Medicine at The University of Texas Health Science Center San Antonio suggests it is possible to fine-tune the properties of this fearsome cancer, making it more sensitive to treatment.

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Researchers develop blood test that accurately detects early stages of lung, breast cancer in humans

 

Researchers at Kansas State University have developed a simple blood test that can accurately detect the beginning stages of cancer.

In less than an hour, the test can detect breast cancer and non-small cell lung cancer — the most common type of lung cancer — before symptoms like coughing and weight loss start. The researchers anticipate testing for the early stages of pancreatic cancer shortly.

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Research identifies a promising new therapeutic target for aggressive breast cancer

Scientists at Western University have identified a new therapeutic target for advanced breast cancer which has shown tremendous promise in mouse models. The study led by Lynne-Marie Postovit of Western’s Schulich School of Medicine & Dentistry looked at a protein called Nodal that is primarily found in embryonic or stem cells. Postovit discovered high levels of this protein in aggressive breast cancer tumors. Nodal was found to promote vascularization in the tumor, providing nutrients and oxygen to help it grow and spread. The research is published online in the journal Cancer Research.

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Accelerated radiation treatment effective for noninvasive breast cancer

 

Accelerated whole breast irradiation after lumpectomy is an effective treatment for ductal carcinoma in situ (DCIS), a very common early stage and noninvasive form of breast cancer, meaning many more breast cancer patients could see their treatment times reduced by half, according to a study in the June issue of the International Journal of Radiation Oncology?Biology?Physics, the official scientific journal of the American Society for Radiation Oncology (ASTRO).

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A new multitarget molecule designed with high potential in future treatments for Alzheimer’s disease

• It acts simultaneously on several targets in the brain
• In vitro studies reveal a reduction in the ß-amyloid peptide aggregation, involved in the disease, and a boost in cognitive function
• It could lead the development of more efficient drugs than those currently used

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New target, new drug in breast cancer

Many breast cancers depend on hormones including estrogen or progesterone for their survival and proliferation. Eight years of lab work at the University of Colorado Cancer Center and elsewhere suggest that the androgen (AR) receptor is an additional hormonal target in many breast cancers. Block AR+ breast cancer’s ability to access androgen and you block the cancer’s ability to survive.

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Hybrid vaccine demonstrates potential to prevent breast cancer recurrence

A breast cancer vaccine already shown to elicit a powerful immune response in women with varying levels of HER2 expression has the ability to improve recurrence rates and is well tolerated in an adjuvant setting, according to new research from a clinical trial led by researchers at The University of Texas MD Anderson Cancer Center.

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Breast cancer effectively treated with chemical found in celery, parsley by MU researchers

Apigenin, a natural substance found in grocery store produce aisles, shows promise as a non-toxic treatment for an aggressive form of human breast cancer, following a new study at the University of Missouri. MU researchers found apigenin shrank a type of breast cancer tumor that is stimulated by progestin, a synthetic hormone given to women to ease symptoms related to menopause.

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Study: Preoperative estrogen-blocking therapy may preempt need for mastectomy

Preoperative treatment with aromatase inhibitors increases the likelihood that postmenopausal women with estrogen receptor-positive breast cancer will be able to have breast-conserving surgery rather than a mastectomy, according to the results of a national clinical trial presented today at the Society of Surgical Oncology annual meeting in Orlando, Fla.

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Researchers discover possible approach to the treatment of aggressive breast cancer

In particularly aggressive forms of breast cancer, cancer cells can settle in other organs and form metastases there. Once such metastases form, complete recovery is rare. Consequently, it is enormously important to prevent the metastasisation of the breast cancer cells. The success, however, achieved by using existing forms of therapy is limited. Scientists from the Max Planck Institute for Heart and Lung Research in Bad Nauheim have now discovered that they can prevent the formation of metastases by blocking the receptor protein Plexin B1. They hope that their discovery will provide a new approach to preventing the metastasisation of aggressive forms of breast cancer, and thus improve the prognosis for patients.

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