BreakThrough Digest - cancer,  medical information

BreakThrough Digest offers current medical news and health articles on medical breakthroughs, medical research and health information on clinical trials, cancer, Alzheimer's, stem-cell research, heart disease, diabetes and more.



HOME

RECENT HEADLINES

NEW RESEARCH

CLINICIAL TRIALS

COMMENTARY

FDA NEWS DIGEST

ADVERTISE

RESOURCES

Quick Links to:

  - Medical Journals
  - Government Health Sites
  - Pharmaceutical Companies
  - Archives
  - A Challenge for Health IT
  - Mobile Edition

Advertisers...

Neprinol
- exclusive distributors of pharmaceutical-grade products including neprinol, syntol, and devacor

Chelation - cardio renew is 100% pure edta providing cardiovascular cleansing by oral chelation.

Oxygen deprived brains repaired and saved

Scientists from Melbourne's Howard Florey Institute have found special proteins that protect the brain after it has been damaged by a lack of oxygen, which occurs in conditions such as stroke, perinatal asphyxia, near-drowning and traumatic brain injury.

Dr Nicole Jones and her team discovered that during oxygen deprivation, or 'hypoxia', these proteins (HIF1 and PHD2) increase.

These proteins regulate processes like the production of red blood cells and new blood vessels, and the flow of glucose to the brain. Therefore they are involved in preventing further brain damage and repairing damage caused by the initial injury.

This discovery takes the Howard Florey Institute's scientists closer to developing preventative and regenerative treatments for brain damage caused by hypoxia.

Dr Jones said her discovery resulted from looking at how the body tries to protect itself and how the brain reacts when it experiences mild, non-damaging hypoxia.

"I found that mild, non-damaging hypoxia actually protected the brain against a subsequent injury by activating certain proteins," Dr Jones said.

"Mild hypoxia appears to pre-condition neural tissues against a mass 'suicide' of healthy neurons after a stroke or other brain trauma.

"In an experiment in rats, mild hypoxia followed by a major stroke resulted in less brain damage than if the rat experienced just a major stroke – all because these protective proteins were increased by the first non-damaging exposure to hypoxia.

"I am now looking at developing both preventative and regenerative treatments that mimic these proteins' protective and repairing effects," she said.

Dr Jones is now testing drug candidates, and would like to develop new drugs that activate these protective proteins in the brain.

While further research is required, Dr Jones and her team are hopeful that their investigations will lead to effective treatments that will help people experiencing hypoxia, and also to improve recovery from hypoxic induced brain damage.

 

 

Google

BreakThrough Digest
Copyright 2007 BreakThrough Digest
BreakThrough Digest subscribes to the eHealth Code of Ethics

 

medical new and medical breakthroughs health information and health articles about medicine on cancer, heart disease, diabetes and stem cell research

medrocket award

Trute